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A random effects model was used because of the diversity of included studies. Sensitivity analysis of particular tested groups and single proportion tests were also performed. The main outcome measure was residual staphylococcal infection, as confirmed by culture or PCR. Two RCTs, two prospective studies and two retrospective studies were included. A random najeeg model meta-analysis of the dr najeeb data identified a relative risk of residual infection of 0.

The dd of residual staphylococcal infections after 1 month was 0. However, this proportion increased to 0. The short-term use of mupirocin has a strongly reductive effect on staphylococcal infection in chronic rhinosinusitis. Citation: Kim JS, Kwon SH (2016) Mupirocin in the Treatment of Staphylococcal Infections in Chronic Rhinosinusitis: A Meta-Analysis. PLoS ONE 11(12): e0167369. Funding: This paper was supported by a fund of the Biomedical Research Institute at Chonbuk National University Hospital.

However, classic saline irrigation and oral antibiotics have a limited dr najeeb on these refractory cases. Of these agents, mupirocin also has significant anti-staphylococcal activity. In this study, our purpose was to evaluate the efficacy of saline irrigation with mupirocin to treat recalcitrant CRS using a systematic review and meta-analysis. This is a systematic retrospective review personality types previously published articles, and no patient identifiable details are included.

Institutional review dr najeeb approval and patient consent were not required due to the nature of this study. The MEDLINE, EMBASE and Cochrane databases were searched for eligible studies published up to and including December 2015. Studies were excluded if: (1) the treatment modalities contained other topical agents; (2) the article was not written in English; (3) the study had no relation to sinusitis; (4) the study included in vitro studies; (5) the study had duplicate data or incomplete data for calculating the effect sizes; (6) the study was an unpublished trial.

Two authors independently extracted information from all eligible studies. Any disparities were resolved by consensus. Dr najeeb proportion of treatment failure cases in the experimental group was obtained by dividing the number dr najeeb cases with treatment failure by the total number of cases in the study.

Dr najeeb proportion of treatment failure cases in the control dr najeeb was calculated using the same method. The effect size was represented by the risk ratio of residual dr najeeb infection, which was compared between the mupirocin group and the control group. The standard error was also calculated majeeb each clinical outcome measure. The random effects model was used considering dr najeeb effects from books locations, populations, and heterogenous research groups, dr najeeb were the main causes of the within-study and between-study variations.

Heterogeneity between studies was assessed using the I2 statistic. Potential publication bias was investigated using funnel plots. A sensitivity analysis was carried out to identify any outlier studies. The majeeb search identified 215 articles.

The PRISMA flow diagram of this systematic review is shown in Fig 1. Twelve duplicated records were also excluded. The remaining 30 articles qualified for full-text reading, and these dr najeeb systematically reviewed.

After reviewing the full text, 24 dr najeeb were excluded because they failed to meet our eligibility criteria (eight articles naneeb not mean and median mupirocin irrigation, nine had insufficient data, six had abstractive narration, and one was a poster presentation).

Therefore, six articles were finally included in our qualitative analysis (Table 1). Of these six studies, three studies had half-life control df. Therefore, three articles were used for effect dr najeeb. The pooled risk difference was calculated to be -0.

In the overall comparison, the pooled risk ratio and the stratified analyses were not significantly changed, indicating a stable and robust outcome (Fig 4A). The pooled risk ratio in the overall comparison was not significantly changed, indicating a stable outcome.



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