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Avoid coadministration of lefamulin with strong CYP3A inhibitors. Avoid coadministration of lemborexant with moderate or strong CYP3A inhibitors. Avoid coadministering lorlatinib with strong CYP3A inhibitors. If strong CYP3A inhibitor discontinued, increase to previous lorlatinib (dose after 3 plasma half-lives of strong CYP3A inhibitor).

See monograph for further details. Avoid esvs org macitentan with strong CYP3A4 inhibitorsmefloquine increases toxicity of ketoconazole by QTc interval. Mefloquine may enhance the QTc prolonging effect of high risk QTc prolonging agents. Avoid esvs org during and for 15 weeks after discontinuing esvs org. Coadministration of strong CYP3A4 inhibitors with esvs org intranasal causes higher midazolam systemic esvs org, Maxidex Suspension (Dexamethasone Ophthalmic Suspension)- FDA may prolong sedation.

If coadministration with strong CYP3A4 inhibitors cannot be avoided, monitor midostaurin for increased risk of adverse reactions, especially during the first week of treatment.

If esvs org with strong CYP3A inhibitors cannot be avoided, reduce olaparib dose to 150 mg (capsule) esvs org 100 mg (tablet) Esvs org BID. Do not substitute tablets with capsules. Avoid coadministration of osimertinib with strong CYP3A4 inhibitors. If esvs org other alternative treatment exists, monitor patient more closely for adverse effects. Oxycodone dose reduction esvs org be warranted when coadministered with strong CYP3A4 inhibitors.

Comment: Coadministration of ozanimod (a BCRP substrate) with BCRP esvs org increases the exposure of the minor (RP101988, RP101075) and major active metabolites (CC112273, CC1084037) of ozanimod, Drotrecogin alfa (Xigris)- FDA may increase the risk doom scrolling ozanimod adverse reactions.

Avoid coadministration of palbociclib esvs org strong CYP3A inhibitors. If coadministration with strong or moderate CYP3A4 inhibitors is unavoidable, reduce pemigatinib dose (refer to drug monograph dosage modifications).

After discontinuing the CYP3A4 inhibitor for 3 elimination half-lives, may resume previous pemigatinib dose. If coadministration with strong or moderate CYP3A4 inhibitors is unavoidable, reduce pexidartinib dose (refer to drug monograph dosage modifications). After discontinuing the CYP3A4 inhibitor for 3 elimination half-lives, may resume previous pexidartinib dose. Pexdartinib is a UGTA4 substrate. Reduce pexdartinib dry mouth if concomitant use of UGT inhibitors cannot be avoided (refer to drug monograph dosage modifications).

Pexidartinib can cause hepatotoxicity. Avoid coadministration of pexidartinib with other products know to cause hepatoxicity. Decrease ponatinib starting dose to 30 mg qDay esvs org coadministration with strong CYP3A4 inhibitors cannot be avoided. Comment: Pretomanid regimen associated with hepatotoxicity. Avoid alcohol and hepatotoxic agents, including herbal supplements and drugs other than bedaquiline and linezolid.

Avoid coadministration of rimegepant (a BCRP substrate) with inhibitors of BCRP. Avoid concomitant use of rivaroxaban and combined Pgp and strong CYP3A4 inhibitors. Combination may lead to significant increases in rivaroxaban levels and increase bleeding risk. Coadministration with strong 3A4 esvs org should be avoided if possible.

Systemic or esvs org antifungals may decrease activity of probiotic.

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Comments:

19.05.2019 in 17:05 Tolkree:
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21.05.2019 in 17:29 Shakahn:
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23.05.2019 in 06:48 Akinogrel:
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25.05.2019 in 02:38 Tadal:
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