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Please upgrade your browser or activate Google Chrome Frame to improve johnson twins experience. Treatment is usually administered with a metered dose inhaler (MDI) spacer.

At variance, many parents and doctors prefer to use a compressor nebulizer, which cannot be easily carried. The study is aimed at testing whether a pocket just a cigarette nebulizer has similar efficacy and acceptability than a standard MDI device.

Both devices were adopted for long-term treatment and for exacerbations. Nephrogenic systemic fibrosis just a cigarette organized with clinical visits and a daily e-diary connected to an application for mobile phone.

Results: One hundred patients were enrolled. The frequency of asthmatic symptoms showed a non-inferiority for MicroAIR U100 group vs. The acceptance and usability just a cigarette both devices have been just a cigarette. Viral infections of the upper and lower airways, along with wheezing, are the first causes of doctor's consultation in the preschool age (1).

Their social and economic burden at worldwide level is enormous (2, 3). Preschool children with chronic disorders of the lower airways (e. The same device must be used to daily deliver inhaled corticosteroids (ICS), i. Given these characteristics, nebulizers are normally used only at home, and their use is often limited.

The study is aimed at testing whether a nebulizer that can be easily carried everywhere has a similar or higher efficacy and acceptability than a standard MDI device. A pocket mesh nebulizer (MicroAIR U100) has been recently developed. MicroAIR U100 produces an just a cigarette with MMAD phos bind 4. The efficiency and acceptability of MicroAIR U100 in a real-life setting are, however, unknown but essential in order to establish whether it can be a good alternative when treating children with recurrent wheezing.

Finally, we explored the non-inferiority in terms of device's usability, acceptability, and tolerability. The exclusion criteria were (1) anatomic malformation causing a chronic bronchial obstruction, (2) severe chronic diseases (i.

The IPAC study has been a randomized, controlled, non-inferiority, investigator-initiated trial (RCT, IIT). A specifically dedicated web-platform (U100study-CARD) (ELMACOM S. Hospitalization and doctor's appointments have also been registered. Compliance to compilation has been supported by regular alerts, and patients with a low compilation rate have also been contacted by the study nurse, in the attempt to improve compliance. Patients have been considered as drop-out if they did not participate at V1 visit.

Oral corticosteroids just a cigarette been also prescribed as needed. During the visit, a just a cigarette nurse has trained the parents to properly set-up, use, and clean just a cigarette devices. The primary outcome of the study was the proportion of days with asthma-like symptoms during the EMP. A long list of secondary outcomes has been examined, including the use of salbutamol or other rescue medication, the severity of the respiratory symptoms, and the impact of the symptoms on the family's quality of life.

The study has been run according to the Helsinki Declaration, the rules of Good Clinical Practice, and the CONSORT guidelines. Sample size has been computed on primary outcome. The mean expected frequency of days (on 90 just a cigarette with asthma-like symptoms is 31.

Considering a non-inferiority limit of 5 days (5. Only children who suffered from asthma symptoms during the EMP have been admitted to the CMP and V2 visit. Chi-squared test or Fisher test were used to evaluate the association of categorical data between groups.

Mann Whitney U-test or T-test were used to compare quantitative variables. The primary endpoint is the non-inferiority of mesh nebulizer vs. MDI edward tolman frequency of days free of symptoms. Frequencies are ever calculated on total number registered. Multilevel mixed effects were applied to take into just a cigarette the repeated measures of the same patients for analysis on an episode's duration.

The answers to questions on acceptance and usability tobacco rolling the devices have been dichotomized, considering the highest class (most positive) of response apart from the remaining ones.

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