Sex life

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Manufactured by: Forest Laboratories Ireland Ltd. Therefore, alterations of urine pH towards the alkaline condition may lead to an accumulation of the drug with a possible increase in adverse effects. Urine pH is altered by diet, drugs (e. Hence, memantine should be used with caution under these conditions. The combined use of NAMENDA with other NMDA antagonists sexx, ketamine, and dextromethorphan) has not been systematically evaluated and such use should be approached with caution.

See FDA-approved patient labeling (PATIENT INFORMATION and Instructions for Use). To assure safe and effective use of NAMENDA, the following information and instructions provided in the patient information section should be discussed with patients and caregivers.

They should be made aware of the patient instruction sex life that is enclosed with the product. Memantine produced no evidence of genotoxic potential when evaluated in the in vitro S. The results were equivocal in an in vitro gene mutation assay using Chinese hamster V79 cells.

There sex life no adequate and well-controlled studies of memantine in pregnant women. NAMENDA should be used during pregnancy only if the potential benefit justifies the potential risk to sed fetus. Slight maternal toxicity and decreased pup weights were also sex life at this dose in a study in which rats were treated from day 15 of gestation through the postpartum period.

Because many drugs are excreted in sx milk, caution should be exercised when NAMENDA is administered to a nursing mother. The efficacy and safety data presented in the sex life trial sections were obtained from these patients. No lif adjustment is needed in patients with mild or moderate hepatic impairment. The largest known ingestion ljfe memantine worldwide was 2. The patient experienced coma, diplopia, and agitation, but subsequently recovered. Fatal outcome has been very rarely reported with memantine, and the relationship to memantine was unclear.

Because strategies sex life the management of overdose are continually evolving, it is advisable to contact a poison control center to determine the latest recommendations for the management of an sex life of any drug. As in any cases of overdose, general supportive measures should be utilized, and treatment fainting be symptomatic.

Elimination of memantine can be enhanced by acidification of urine. NAMENDA (memantine hydrochloride) is contraindicated in patients with known hypersensitivity to memantine hydrochloride or to any excipients used in the formulation.

Memantine is postulated to exert its sex life effect through its sex life as a low to moderate affinity uncompetitive (open-channel) NMDA receptor antagonist which binds preferentially to the NMDA receptor-operated cation channels.

Memantine also showed antagonistic effects at the 5HT3 receptor with a potency similar to that for the NMDA receptor and blocked nicotinic sex life burning in the third degree with one-sixth to one-tenth the potency. In vitro studies have shown that memantine does not affect the reversible inhibition of sex life by donepezil, galantamine, or tacrine.

Following oral administration memantine is highly absorbed with peak concentrations reached in about 3-7 hours. Memantine has linear pharmacokinetics over the therapeutic dose range. Food has no effect on the absorption of memantine.

Memantine undergoes partial hepatic metabolism. The hepatic microsomal CYP450 enzyme system does not play a significant role in the metabolism of memantine. The remainder is converted primarily to three polar metabolites which possess sex life NMDA receptor antagonistic activity: the N-glucuronide conjugate, 6-hydroxy memantine, and 1-nitroso-deaminated memantine.

Renal clearance involves active tubular secretion moderated by pH sex life tubular reabsorption. No dosage adjustment is recommended for patients with mild and moderate renal impairment. Memantine pharmacokinetics were evaluated following sec sex life of single oral doses of sex life mg in 8 subjects with moderate hepatic impairment (Child-Pugh Class B, score 7-9) and 8 sex life who were age- gender- and weight-matched to the hepatically-impaired subjects.

There was no change in memantine exposure (based on Cmax and AUC) in subjects with moderate hepatic impairment as compared with healthy subjects.

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